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| Hartsville, South Carolina, is located in the northeastern portion of South Carolina, about 30 miles from where Interstates 95 and 20 join. | |
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| City | Miles |
| Darlington, South Carolina | 13 |
| Florence, South Carolina | 25 |
| Columbia, South Carolina | 70 |
| Myrtle Beach, South Carolina | 80 |
| Charleston, South Carolina | 134 |
| Asheville, North Carolina | 220 |
| Atlanta, Georgia | 260 |
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